The Ministry of Science and ICT announced on January 16 that a research team led by Professor Oh Deok-kun of Konkuk University developed a substance similar to lipid regulating agents in human body using microbial enzyme and confirmed the potential as a drug for diabetes.
The research team successfully compounded substances, such as hepoxilin and trioxilin which are lipid regulating agents that control glucose metabolism with a minute amount of them existing in human body. Lipid regulating agents is a substance that is involved in various biological activities in the body, including immunity, anti-inflammatory and controlling glucose and fat metabolism. Since only a small amount of substances are created in the body and they are dissolved very quickly, it has been impossible to secure the substance until now.
In addition, the research team studied an enzyme and metabolic pathway involving in biosynthesis of lipid regulating agents from germs. They found proteinlike in microorganism, which has the same function of lipoxidase and hydroxy fatty acid enzyme that compound lipid regulating agents in the body, and use them to biologically synthesize numerous lipid regulating agents.
Professor Oh Deok-kun said, “We succeeded in mass developing and producing lipid regulating agents that only a minute amount of them can be found in human body, by making use of microorganism. We will be able to biologically synthesize various lipid regulating agents that can treat diabetes and infection in the future.”
The latest findings were published in the international journal Nature Communications.